Nutritional Epidemiology

PhD, affiliated reseacher

Stina Ramne is a registered dietitian and holds a MSc in Clinical Nutrition from University of Gothenburg (2017). In 2017, Stina began her PhD studies in the Nutritional Epidemiology group. She defended her thesis in 2021 and is still affiliated to the group. Her projects study the link between consumption of added sugars and risk of cardiometabolic disease through various potential pathways, including inflammatory pathways and the gut microbiota.

In 2019, Stina was appointed as president of the Southern Swedish Nutrition Society (Swedish: Sydsvensk Förening för Nutrition (SFN)), a post that she still holds to this day.

Stina’s main interest has always been in the prevention of obesity and diabetes, and related diseases. Stina’s most recent interest is in the discovery of objective measurements of sugar intake in the form of nutritional biomarkers, such as urinary sucrose and fructose.

Read Stina’s blog posts here

Publications

• Sucrase isomaltase dysfunction reduces sucrose intake in mice and humans
  November 14, 2024 by Peter Aldiss
  No abstract
• Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data
  October 19, 2024 by Stina Ramne
  CONCLUSIONS: These findings support the feedback diet-regulatory mechanism of FGF21 in humans, but highlights the need for mechanistic characterization of the complex FGF21 genetic region.
• Are we using more sugar substitutes? Wastewater analysis reveals differences and rising trends in artificial sweetener usage in Swedish urban catchments
  June 25, 2024 by Inga Haalck
  The market for artificial sweeteners as substitutes for conventional sugar (sucrose) is growing, despite potential health risks associated with their intake. Estimating population usage of artificial sweeteners is therefore crucial, and wastewater analysis can serve as a complement to existing methods. This study evaluated spatial and temporal usage of artificial sweeteners in five Swedish communities […]
• Clusters of carbohydrate-rich foods and associations with type 2 diabetes incidence: a prospective cohort study
  December 19, 2023 by Kjell Olsson
  CONCLUSIONS: A dietary pattern defined by a high intake of fruits was associated with a lower incidence of type 2 diabetes. The findings provide additional evidence of a potential protective effect from fruit intake in reducing type 2 diabetes risk. Future studies are needed to explore this association further.
• Comparisons of Different Carbohydrate Quality Indices for Risk of Type 2 Diabetes in the Malmö Diet and Cancer Study
  September 28, 2023 by Michaela Ramstedt
  Carbohydrate quality might be more important than quantity to reduce type 2 diabetes (T2D) risk. Various metrics of carbohydrate quality exist; however, their associations with T2D have only been studied to a limited extent. Consequently, the aim was to investigate the association between four different pre-defined carbohydrate quality indices, with various amounts of fiber (≥1 […]
• Meal sugar-protein balance determines postprandial FGF21 response in humans
  September 20, 2023 by Stina Ramne
  Biological mechanisms to promote dietary balance remain unclear. Fibroblast growth factor 21 (FGF21) has been suggested to contribute to such potential regulation considering that FGF21 1) is genetically associated with carbohydrate/sugar and protein intake in opposite directions, 2) is secreted after sugar ingestion and protein restriction, and 3) pharmacologically reduces sugar and increases protein intake […]
• Genetic Loss of Sucrase-Isomaltase Function: Mechanisms, Implications, and Future Perspectives
  March 30, 2023 by Ninna Karsbæk Senftleber
  Genetic variants causing loss of sucrase-isomaltase (SI) function result in malabsorption of sucrose and starch components and the condition congenital sucrase-isomaltase deficiency (CSID). The identified genetic variants causing CSID are very rare in all surveyed populations around the globe, except the Arctic-specific c.273_274delAG loss-of-function (LoF) variant, which is common in the Greenlandic Inuit and other […]
• Reply to LT Cacau and DM Marchioni
  April 1, 2022 by Anna Stubbendorff
  No abstract
• Single Nucleotide Polymorphisms in Close Proximity to the <em>Fibroblast Growth Factor 21 (FGF21)</em> Gene Found to Be Associated with Sugar Intake in a Swedish Population
  November 27, 2021 by Suzanne Janzi
  Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., monosaccharides and sucrose) in a middle-aged Swedish population. Two […]
• Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study
  November 18, 2021 by Mary Farrell
  CONCLUSIONS: Starch intake modified the observed association between AMY1 CNV and fasting glucose and BMI. Furthermore, depending on the starch dose, a higher postprandial glucose and insulin response was observed in individuals with high AMY1 CN than in those with low AMY1 CN.